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Download e-book for kindle: A Leg to Stand On by Oliver Sacks

By Oliver Sacks

ISBN-10: 0671467808

ISBN-13: 9780671467807

The writer of twelve books, together with the bestselling Awakenings, the guy Who Mistook His spouse For a Hat, Musicophilia, and Hallucinations, Oliver Sacks is the world over popular for his compassionate method of sufferers stricken by profound neurological problems. but whilst an coincidence on an uninhabited mountain in Norway leaves Dr. Sacks with a serious leg damage, he turns into the sufferer. in the course of what must have been a regimen restoration interval, he reports an overpowering sensation that his injured leg is now absent from his physique, and certainly from his actual expertise. In A Leg to face On, one among Dr. Sacks’ such a lot own works, this stressful event is the start line of a desirable trip throughout the mysteries of belief, the actual substance of our identities, and the event of being a patient.

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Extra resources for A Leg to Stand On

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In addition, is was recently shown that the transcription factor IRF-5, which forms a complex with MyD88 and TRAF6, also functions as a general signal tranducer that mediates MyD88-dependent gene induction of pro-inflammatory cytokines [10]. Next to this so-called MyD88-dependent pathway, a MyD88-independent route, exists which is used only by TLR4 and TLR3 [9]. The MyD88-independent route will result in the delayed activation of NF-jB and the production of interferon (IFN)-b. Furthermore, it is now known that different TLRs use different adaptor molecules.

Zeng S, Feirt N, Goldstein M, et al (2004) Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice. Hepatology 39:422±432 34. Cataldegirmen C, Zeng S, Feirt N, et al (2005) RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-a and NF-jB. J Exp Med 201:473±484 35. Chavakis T, Bierhaus A, Al-Fakhri N, et al (2003) The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment.

To overcome this problem, RAGE±/± mice were studied. In a setting of autoimmune encephalomyelitis, serving as a model to test the role of RAGE in the adaptive immune response, no differences between wildtype and RAGE-knock-out mice could be detected [32]. Interestingly, RAGE transgenic mice showed significantly enhanced clinical autoimmune encephalomyelitis scores. In addition, in a second model (delayed-type hypersensitivity), RAGE±/± mice and wildtype species developed the same inflammatory response.

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A Leg to Stand On by Oliver Sacks

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