By Oliver Sacks
The writer of twelve books, together with the bestselling Awakenings, the guy Who Mistook His spouse For a Hat, Musicophilia, and Hallucinations, Oliver Sacks is the world over popular for his compassionate method of sufferers stricken by profound neurological problems. but whilst an coincidence on an uninhabited mountain in Norway leaves Dr. Sacks with a serious leg damage, he turns into the sufferer. in the course of what must have been a regimen restoration interval, he reports an overpowering sensation that his injured leg is now absent from his physique, and certainly from his actual expertise. In A Leg to face On, one among Dr. Sacks’ such a lot own works, this stressful event is the start line of a desirable trip throughout the mysteries of belief, the actual substance of our identities, and the event of being a patient.
Read Online or Download A Leg to Stand On PDF
Similar medicine books
This booklet is written for the clients and architects of joint replacements. In its moment prolonged variation it conveys to the reader the data collected by means of the authors in the course of their 40 12 months attempt at the improvement of substitute units for the decrease limb for the aim of helping the reader of their layout and evaluate of joint substitute units.
Biochemistry for doctors comprises pivotal advances within the biochemistry box and gives a source for execs throughout medication, dentistry, pharmaceutical sciences and overall healthiness professions who desire a concise, topical biochemistry reference.
Relevant, well-illustrated assurance starts off with the composition of the human physique after which is going into the technical aspect of the metabolism of the human physique and biochemistry of inner organs sooner than that includes a biotechnology learn along with quite a few tools and applications.
The paintings is written at a always excessive point, with technical notes further to help comprehension for complicated topics.
Illustrates affliction involvement in metabolic maps
Contains insurance of state-of-the-art know-how, together with iPS, HPLC and HPLC-MS, and FACS method
Provides in-depth technical element in addition to conceptual frameworks of biochemistry and experimental layout within the context of the human organism
Includes a biotechnology research, that includes program of uncomplicated biochemistry rules
The well-known publication by means of Revici, unavailable everywhere.
It comes from the college of Michigan, digitized by way of google.
- Viral Nanotechnology
- Chronic Obstructive Pulmonary Disease: Cellular and Molecular Mechanisms
- Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics: Neue Foige
- Blueprints Family Medicine (3rd Edition)
- Problem-Based Microbiology
- The gist of emergency medicine : the management of real or simulated patient encounters
Extra resources for A Leg to Stand On
In addition, is was recently shown that the transcription factor IRF-5, which forms a complex with MyD88 and TRAF6, also functions as a general signal tranducer that mediates MyD88-dependent gene induction of pro-inflammatory cytokines . Next to this so-called MyD88-dependent pathway, a MyD88-independent route, exists which is used only by TLR4 and TLR3 . The MyD88-independent route will result in the delayed activation of NF-jB and the production of interferon (IFN)-b. Furthermore, it is now known that different TLRs use different adaptor molecules.
Zeng S, Feirt N, Goldstein M, et al (2004) Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice. Hepatology 39:422±432 34. Cataldegirmen C, Zeng S, Feirt N, et al (2005) RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-a and NF-jB. J Exp Med 201:473±484 35. Chavakis T, Bierhaus A, Al-Fakhri N, et al (2003) The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment.
To overcome this problem, RAGE±/± mice were studied. In a setting of autoimmune encephalomyelitis, serving as a model to test the role of RAGE in the adaptive immune response, no differences between wildtype and RAGE-knock-out mice could be detected . Interestingly, RAGE transgenic mice showed significantly enhanced clinical autoimmune encephalomyelitis scores. In addition, in a second model (delayed-type hypersensitivity), RAGE±/± mice and wildtype species developed the same inflammatory response.
A Leg to Stand On by Oliver Sacks