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Download PDF by J. Victor Small, Klemens Rottner (auth.), Marie-France: Actin-based Motility: Cellular, Molecular and Physical

By J. Victor Small, Klemens Rottner (auth.), Marie-France Carlier (eds.)

ISBN-10: 9048193001

ISBN-13: 9789048193004

This publication provides the mobile, molecular and actual facets of strength and flow by way of the self-assembly of actin, some of the most plentiful proteins present in cells, into cytoskeletal filaments. « Actin-based motile strategies » are accountable for a wide number of motile actions corresponding to chemotactic locomotion, embryonic and metastatic phone migration, wound therapeutic, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic actions, in addition to morphogenetic approaches together with, axis patterning in early embryos, axonal development in mind improvement, and the immune reaction and synaptic plasticity procedures on the beginning of studying and reminiscence. The ebook describes how the lately undertaken multidisciplinary and multiscale ways have explored the molecular and actual mechanisms on the foundation of strength and circulation produced by way of actin self-assembly. the selected issues exhibit how advances were made within the box of mobilephone motility as a result development in reside mobile imaging, gentle microscopy, more desirable answer within the constitution of huge protein assemblies, the biochemical research and mathematical modeling of actin meeting dynamics and the improvement of nanotechnologies allowing us to degree forces within the diversity of pico- to nano-newtons produced via actin assemblies.

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Read e-book online Actin-based Motility: Cellular, Molecular and Physical PDF

This e-book provides the mobile, molecular and actual points of strength and flow by way of the self-assembly of actin, essentially the most considerable proteins present in cells, into cytoskeletal filaments. « Actin-based motile tactics » are accountable for a wide number of motile actions akin to chemotactic locomotion, embryonic and metastatic mobile migration, wound therapeutic, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic actions, in addition to morphogenetic strategies together with, axis patterning in early embryos, axonal progress in mind improvement, and the immune reaction and synaptic plasticity techniques on the beginning of studying and reminiscence.

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Extra info for Actin-based Motility: Cellular, Molecular and Physical Aspects

Example text

247–264. A. Weed. 2008. Cortactin branches out: roles in regulating protrusive actin dynamics. Cell Motil Cytoskeleton. 65:687–707. N. P. Cramer. 2008. Retrograde flow and myosin II activity within the leading cell edge deliver F-actin to the lamella to seed the formation of graded polarity actomyosin II filament bundles in migrating fibroblasts. Mol Biol Cell. 19:5006–18. D. Pollard. 2006. Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin.

Curr Opin Cell Biol. 18:18–25. , J. Chou, H. Falet, R. H. P. Stossel. 2001. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 155:511–17. C. 2004. Newest findings on the oldest oncogene; how activated src does it. J Cell Sci. 117:989–98. J. E. Bear, J. B. S. Sechi. 2002. Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization.

2004. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell. 118:363–73. , B. M. Kessels, and W. Almers. 2004. Neural Wiskott Aldrich Syndrome Protein (N-WASP) and the Arp2/3 complex are recruited to sites of clathrinmediated endocytosis in cultured fibroblasts. Eur J Cell Biol. 83:13–8. , and M. Kirschner. 1988. Cytoskeletal dynamics and nerve growth. Neuron. 1: 761–72. , H. Miki, H. He, H. Maruta, and T. Takenawa. 2002. Essential role of neural WiskottAldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.

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Actin-based Motility: Cellular, Molecular and Physical Aspects by J. Victor Small, Klemens Rottner (auth.), Marie-France Carlier (eds.)


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