By Craig Meyers
One of crucial facets of AIDS is the lack of protecting immune functionality within the contaminated host which results in elevated occurrence of opportunistic infections and cancers. This publication in particular addresses viral-induced human cancers linked to AIDS and saw within the AIDS inhabitants. It addresses the explicit therapy required during this specific inhabitants and the molecular biology of the causative viral agents.
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Extra resources for AIDS-Associated Viral Oncogenesis (Cancer Treatment and Research)
Antineoplastic treatment of AIDS-associated HL has many problems considering the underlying immunodeficiency caused by HIV itself that is further compromised by additional chemotherapy. 110 Gerard and colleagues129 in a retrospective study over 15 years estimated the 2-year survival probability was 45% in the pre-HAART period, and 62% in the post-HAART period. 131 Chemotherapy and HAART Several prospective trials to date have now been done using antiretrovirals concomitantly with different chemotherapy regimens.
Although these cancers were not classic “Opportunistic Infections,” it eventually became clear that these cancers were associated with coinfections with oncogenic viruses among HIV-infected individuals. In fact, the unique epidemiology of KS subsequently led to the identification of the novel human herpes virus, HHV-8. Other oncogenic viruses that are linked to HIV-associated malignancies include Epstein-Barr virus (EBV) and human papillomavirus (HPV). These three viruses have now been linked to other HIVassociated malignancies, including Hodgkin’s lymphoma (HL), leiomyosarcoma, multicentric Castleman’s disease (MCD), primary effusion lymphoma (PEL), and anal cancer.
Two of ten patients survived beyond a year, and half of the patients did not respond to treatment. 42 Role of HAART HAART should be initiated in all individuals with AIDS-related PCNSL that are undertaking treatment. In the pre-HAART era, RT prolonged survival for Table 1. Chemotherapy Regimens for AIDS-Related PCNSL Study No. 5, 4, 7, 22+, 13+* One patient received radiation, one responded but required another treatment (surviving 7 months), and one patient was lost to follow-up after treatment.
AIDS-Associated Viral Oncogenesis (Cancer Treatment and Research) by Craig Meyers