By Hans Ulrich Wahn, Hugh A. Sampson MD
Allergy, Immunity and Tolerance in Early adolescence: the 1st Steps of the Atopic March provides important insights at the atopic illnesses, together with bronchial asthma, allergic rhinitis, atopic dermatitis, and foodstuff bronchial asthma, that have constructed into significant illnesses in such a lot components of the realm.
As the traditional heritage of those continual ailments has been widely studied, together with their significant genetic, environmental, and way of life determinants and strength protecting components, the booklet offers strategies on how pediatric allergists grants early intervention. furthermore, the publication unites key, international specialists within the box who summarize their collective, and present, wisdom of the early degree of the "Atopic March", besides novel principles for strength ideas of prevention.
- Summarizes the present wisdom of the epidemiological, genetic, and mobile foundation of allergic diseases
- Ideal reference for the research of asthma in children, atopic dermatitis, allergic rhinitis, early life bronchial asthma, and meals allergies
- Provides landmark findings within the box of immunology and hypersensitive reaction development
- Fulfills the necessity for a e-book that specializes in fundamental and secondary hypersensitive reaction prevention, particularly in the course of the first years of life
- Unites key, worldwide specialists within the box who summarize their collective, and present, wisdom, besides novel rules for capability thoughts of prevention
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Extra info for Allergy, immunity and tolerance in early childhood : the first steps of the atopic March
J Allergy Clin Immunol 2007;119:718–25. von Berg A, Filipiak-Pittroff B, Krämer U, Hoffmann B, Link E, Beckmann C, et al. Allergies in high risk school children after early intervention with cow’s milk protein hydrolysates: 10 year results from the German Infant Nutritional Intervention Study (GINI). J Allergy Clin Immunol 2013;131:1565–73. Lau S, Gerhold K, Zimmermann K, Ockeloen CW, Rossberg S, Wagner P, et al. Oral application of bacterial lysate in infancy decreases the risk of atopic dermatitis in children with 1 atopic parent in a randomized, placebo-controlled trial.
House dust mite allergen levels in individual bedding components in New Zealand. N Z Med J 2002;115:151–3. Erwin EA, Rönmark E, Wickens K, Perzanowski MS, Barry D, Lundbäck B, et al. Contribution of dust mite and cat specific IgE to total IgE: relevance to asthma prevalence. J Allergy Clin Immunol 2007;119:359–65. Lau S, Illi S, Sommerfeld C, Niggemann B, Bergmann R, von Mutius E, et al. Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study.
What kind of additional information is needed to better address these questions? First, we would need birth cohort studies with shorter intervals between blood samples (<1 year) to allow more accurate association analyses between symptoms and serology during the early steps of the sensitization process. Then, we would need to express our sensitization results in quantitative assays instead of the dichotomous classification mostly used. It is essential to compare IgE results with IgG antibody data in patients and controls, and to look for an explanation of the striking differences among allergens in the IgE/IgG ratios.
Allergy, immunity and tolerance in early childhood : the first steps of the atopic March by Hans Ulrich Wahn, Hugh A. Sampson MD